Royal Air Force Typhoon FGR4s have joined forces with France's air force in a combined operation targeting an hidden munitions depot in Syrian territory operated by the IS group, according to the UK's MoD.
The facility, located using reconnaissance, was thought to be housing weapons and explosive materials, the release indicated, and was situated in mountainous terrain just to the north of Palmyra in central Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to strike a series of approach shafts leading to the facility... initial indications indicate the strike was effective," the ministry announced.
There was no indication of any harm to civilians in the attack late on Saturday and every plane involved returned safely, the MoD added.
The British jets were supported by a Voyager refuelling tanker.
The Islamic State group - referred to as ISIS - enforced jihadist rule over significant areas in Syria and Iraq before its territorial defeat in 2019.
"This operation shows the UK's leading role, and commitment to operate in unison with our partners, to eradicate any revival of IS and their dangerous and violent ideologies in the Middle East," UK Defence Secretary the Defence Secretary stated.
British military aircraft have performed patrols over Syria to "prevent any attempted comeback" of the group after its defeat at the climactic battle in Baghuz in the year 2019, the authorities noted.
"I want to thank all the members of our armed forces involved in this strike for their expertise and their courage," he added. "They were part of numerous British troops stationed over Christmas and New Year. This action, to eliminate militants who pose a risk to our way of life, highlights how UK forces are always on standby, all year round, ensuring Britain's security within its borders and powerful internationally."
During December, the United States armed forces carried out what it called a "major assault" on Islamic State objectives in Syria, subsequent to an ambush resulted in the deaths of two American soldiers and a local interpreter in Palmyra.
The U.N. reports Daesh still has roughly 5-7 thousand combatants in both countries.